Manifestation and Management of Paraquat Intoxiction. A deadly poison?
نویسندگان
چکیده
Paraquat is a bipyridilium herbicide, is a bright green corrosive liquid with pungent smell that needs to be diluted before agricultural use. Globally it is the second highest-selling weed killer used and is available in a 20% solution form.[1] Its herbicidal properties were discovered in 1950s and first marketed in 1962. Most cases of intoxication especially in third-world countries are due to suicidal attempts instead of homicidal or accidental exposure, because of its widespread availability and relative low cost. The lethal dose /toxic dose is very low 35mg/kg that is (10 mL or 2 teaspoons is enough to kill) . It is a highly toxic compound and has multisystemic effects which include are pulmonary edema, convulsions, cardiac, renal, and hepatic failure[2] . Key words; Paraquat, Herbicide, Acute respiratory distress syndrome andmulti organ failure.
منابع مشابه
Ameliorative Effect of Crocin on Sperm Parameters and In Vitro Fertilization in Mice under Oxidative Stress Induced by Paraquat
Objective Background and Objectives: Paraquat (PQ) is a herbicide and is genotoxic and cytotoxic poison for male germ cells. Therefore, in this study, the protective role of Crocin (Cr) against the destructive effects of Paraquat on sperm quality and in-vitro fertilization results Paraquat was investigated. MaterialsAndMethods Materials and Methods: Twenty-eight male mice (20-25g) were used in ...
متن کاملPredictive values of urine paraquat concentration, dose of poison, arterial blood lactate and APACHE II score in the prognosis of patients with acute paraquat poisoning
The present study investigated the predictive values of urine paraquat (PQ) concentration, dose of poison, arterial blood lactate and Acute Physiology and Chronic Health Evaluation (APACHE) II score in the prognosis of patients with acute PQ poisoning. A total of 194 patients with acute PQ poisoning, hospitalized between April 2012 and January 2014 at the First Affiliated Hospital of P.R. China...
متن کاملThe Achievements of the Poison Control Center of Bach Mai Hospital, Vietnam
Last editorial of the Asia Pacific Journal of Medical Toxicology addressed the important role of poison control centers in the improvement of public health (1). In Vietnam, poison control center (PCC) of Bach Mai Hospital has been the only national one for civilians. The establishment and activities of this center can be considered as one of the pioneers in the East Asia. History and setting (2...
متن کاملComment on "Medical Management and Outcome of Paraquat Poisoning in Ahvaz, Iran: A Hospital-Based Study"
Dear editor, We read the recent article of Rahmani et al entitled "Medical Management and Outcome of Paraquat Poisoning in Ahvaz, Iran: A Hospital-Based Study" in your journal (1). In their study they performed upper gastrointestinal (GI) endoscopy as a routine for all paraquat poisoned patients, because they considered paraquat a caustic agent and that it may cause severe mucosal injuries in e...
متن کاملATTENUATION OF PARAQUAT TOXICITY IN MICE
Paraquat (PQ) is a widely used herbicide. However, a large number of cases of accidental or suicidal poisoning from PQ has been reported. Membrane damage induced by lipid peroxidation, inactivation of protein or damage to DNA by radical formation have been suggested as toxicity mechanisms of PQ. In the present work, the effects of atropine, propranolol, procainamide and dipyridamole on PQ-...
متن کامل